Which of the following is the best method to minimize misuse and ensure the privacy of electronic clinical information?

Setting up role-based access for users is the best method to minimize misuse and ensure the privacy of electronic clinical information. This approach involves defining permissions based on the specific roles of users within an organization, which helps limit access to sensitive data only to those who truly need it for their job functions. By ensuring that individuals have access only to the information necessary for their roles, the risk of unauthorized access and potential data breaches is significantly reduced.

Role-based access control (RBAC) provides a structured way to implement security measures that can adapt to varying levels of user responsibilities, thus fostering a more secure environment for sensitive patient information. Additionally, this method facilitates compliance with regulations like HIPAA, which mandates strict control over access to protected health information (PHI).

While other methods mentioned, such as biometric authentication and periodic password changes, contribute to security, they do not address the critical aspect of tailoring data access to job roles. Implementing a signed security agreement reinforces accountability but is ineffective as a standalone measure for controlling access to electronic clinical information.